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KMID : 0191120160310030417
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Journal of Korean Medical Science
2016 Volume.31 No. 3 p.417 ~ p.422
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Correlations between the CagA Antigen and Serum Levels of Anti-Helicobacter pylori IgG and IgA in Children
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Seo Ji-Hyun
Lim Chun-Woo
Park Ji-Sook
Yeom Jung-Sook
Lim Jae-Young
Jun Jin-Su
Woo Hyang-Ok
Youn Hee-Shang
Baik Seung-Chul
Lee Woo-Kon
Cho Myung-Je
Rhee Kwang-Ho
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Abstract
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We tested correlations between anti-Helicobacter pylori IgG and IgA levels and the urease test, anti-CagA protein antibody, degree of gastritis, and age. In total, 509 children (0?15 years) were enrolled. Subjects were stratified as 0?4 years (n = 132), 5?9 years (n = 274), and 10?15 years (n = 103) and subjected to the urease test, histopathology, ELISA, and western blot using whole-cell lysates of H. pylori strain 51. The positivity rate in the urease test (P = 0.003), the degree of chronic gastritis (P = 0.021), and H. pylori infiltration (P < 0.001) increased with age. The median titer for anti-H. pylori IgG was 732.5 IU/mL at 0?4 years, 689.0 IU/mL at 5?9 years, and 966.0 IU/mL at 10?15 years (P < 0.001); the median titer for anti-H. pylori IgA was 61.0 IU/mL at 0?4 years, 63.5 IU/mL at 5?9 years, and 75.0 IU/mL at 10?15 years (P < 0.001). The CagA-positivity rate was 26.5% at 0?4 years, 36.5% at 5?9 years, and 46.6% at 10?15 years for IgG (P = 0.036), and 11.3% at 0?4 years, 18.6% at 5?9 years, and 23.3% at 10?15 years for IgA (P < 0.001). Anti-H. pylori IgG and IgA titers increased with the urease test grade, chronic gastritis degree, active gastritis, and H. pylori infiltration. Presence of CagA-positivity is well correlated with a high urease test grade and high anti-H. pylori IgG/IgA levels.
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KEYWORD
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Antibodies IgG/IgA, Helicobacter pylori, CagA Protein, Urease, Children
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